In one case report, serious hypotension took place during splitting up from cardiopulmonary bypass in an individual given intrathecal clonidine.

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Rebound high blood pressure might be decreased by gradual decrease of dose over 2 to four days.

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A comparison throughout research studies recommends that the Cmax is 50 % lower for clonidine hydrochloride extended-release tablet computers compared to immediate-release clonidine hydrochloride.